eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 September, 2017 13 5 106 111 http://dx.doi.org/10.22147/juc/130503 565 article SHUCHITA AGRAWAL (mrs.shuchitaagrawal@yahoo.com) 1 AJIT JOSHI 1 SANCHITA JAIN 1 Departement of Chemistry Mewar University, Chittorgarh (Rajasthan) (India) <p style="text-align: justify;">The anticancer drug Chlorambucil and its complex with Fe (II) have been qualitative and quantitative analyzed spectrometrically and electrochemically.<br /> All the studies have been done in both phases i.e. solid and liquid. On the basis of elemental analysis, IR spectrometry, Polarography and Amperometric methods the probable formula of the complex has been worked out to be 1:2 (M: L).<br /> Antimicrobial activity of complex has been determined using Disc diffusion method against various pathogenic bacteria and fungi. Obtained results is increased inhibition efficiency against the prepared complex, it is presumed that the complex may prove to be more potent as compared to Chlorambucil drug.<br /> Pharmacological studies (In-Vitro and In-vivo) of prepared drug complex were done on sarcoma-180 tumor cell. The observed results revealed that the complex is more potent as compared to the pure drug in all above mentioned activities. As such Fe (II) Chlorambucil drug complex may be recommended to the therapeutic expert for its possible use as more potent anticancer drug.</p> https://journalofchemistry.org/paper/565/ Bioinorganic anticancer drug Iron complex polarography pharmacology