eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 November, 2017 13 6 132 139 http://dx.doi.org/10.22147/juc/130601 569 article POOJA 1 VINITA GUPTA 2 SANCHITA SINGH 2 Y.K. GUPTA (ykgbkbiet123@gmail.com) 3 Department of Chemistry, Janta Vidya Mandir Ganpat Rai Rasiwasia (J.V.M.G.R.R.) P.G. College, Charkhi Dadri, Haryana (India) Department of Chemistry, Agra College, Agra, U.P, (India) Head Department of Chemistry, B K Birla Institute of Engineering and Technology, Pilani, Rajasthan, (India) <p style="text-align: justify;">Schiff bases are aldehyde- or ketone-like compounds in which the carbonyl group is replaced by an imine or azomethine group. They are widely used for industrial purposes and also exhibit a broad range of Antimicrobial Activity. The extreme efforts have been developed to design novel series of Schiff &lsquo;s bases with triazole ring (8a and 8b) have been synthesized from 4-Amino-5-((4-amino-5-phenyl-4H-1,2,4-Triazol-3- ylthio)methyl)-4H-1,2,4-Triazole-3-thiol (7), which is built by multiple consecutive cyclization reactions starting from benzoic acid hydrazide (1). Infrared spectroscopy and melting points were used to characterize the synthesized compounds. The biological activity of compounds (7) and (8a and 8b) were evaluated toward gram negative bacteria (Escherichia coli) and gram positive bacteria (staphylococcus aureus).</p> https://journalofchemistry.org/paper/569/ Schiffu2019s Base, 1,2,4-Trizole Antimicrobial Activity