eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 August 2010 6 2 123 128 juc 603 article A. Sreelakshmi 1 G. Devala rao 2 G. Sudhakara Sai Babu 2 Department og Biotechnology, Monteshsori Mahila Kalasala, Vijaywada- 520010 Andhra Pradesh (INDIA) K.V.S.R. Siddartha College of Pharmaceutical Science, Vijaywada- 520010 A.P. (INDIA) <p>Ziprasidone is a typical antipsychotic agent. Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Ziprasidone hydrochloride (ZPD) in pure state and in its pharmaceutical formulations. The developed<strong> </strong>Method A is based on the reaction of the drug with 3-methyl-2-benzothiazolinone hydrazone in the presence of ferric chloride to form a colored species with &euml;_max 640 nm and Linearity in the range of 8-56 &igrave;g/mL. Method B involves ion association complex formation of the drug with Methyl Orange. The developed chromogen in Method B shows maximum absorption at &euml;_max 420 nm and Linearity in the range of 3-15 &igrave;g/mL.<strong> </strong>The results obtained were statistically evaluated and were found to be accurate and reproducible. &nbsp;</p> https://journalofchemistry.org/paper/603/ Ziprasidone Spectrophotometric ZPD