Synthesis and characterization of 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione derivatives and study of their antimicrobial activities

eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 April 2010 6 1 15 18 juc 626 article Synthesis and characterization of 4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione derivatives and study of their antimicrobial activities R.A. Shah (Rajivmansa#yahoo.co.in) 1 P. S. Patel (pspatel_mansa@yahoo.co.in) 1 D.K. Trivedi 1 P.J. Vyas 2 Department of Chemistry Sheth l.H. Science College, MANSA-382845 (INDIA) Department of Chemistry, Sheth M.N. Science College, Patan -384265 (INDIA)  4-{4-(2-phenyl-4-benzylidene-5-oxo-imidazol-1-yl) phenyl}-6-(substituted phenyl)-1,2,5,6-tetrahydropyrimidin-2-thione have been prepared by the refluxation for 3 hours of 4-benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2- phenyl -imidazol-5-one with thiourea and potassium hydroxide in presence of ethanol . The intermediate 4-benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2- phenyl -imidazol-5-one synthesized by the condensation of 1-(4-acetylphenyl)-4-benzylidene-2- phenyl- imidazol-5-one with various aldehydes. The product is characterized by spectral and analytical data. Most of the tested compounds show promising antibacterial and antifungal activity.     https://journalofchemistry.org/paper/626/ mercapto substitutedChalcones dihydropyrimidin