eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 April 2010 6 1 118 122 juc 643 article A. Sreelakshmi 1 G. Devala rao 2 G. Sudhakara Sai Babu 2 Depaertment of Biotechnology, Montessori Mahila Kalasala, Vijaywada -520010, Andhra Pradesh (INDIA) K.V.S.R., Siddhartha College of Pharmaceutical Science, Vijaywada - 520010 Andhra Pradesh (INDIA) <p style="text-align: justify;"><br /> Ziprasidone is a typical antipsychotic agent. Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Ziprasidone hydrochloride (ZPD) in pure state and in its pharmaceutical dosage forms. The developed<strong> </strong>Method A is based on the formation of picrate salt between Picric acid and free base of ziprasidone and it shows maximum absorption at &euml; _max 400 nm and Linearity in the range of 4-20 &igrave;g/mL. Method B involves reaction between free base of ziprasidone and Chloranilic acid. The developed chromogen in Method B shows maximum absorption at &euml; _max 520 nm and Linearity in the range of 16-36 &igrave;g/mL.<strong> </strong>The results obtained were statistically evaluated and were found to be accurate and reproducible.</p> <p>&nbsp;</p> https://journalofchemistry.org/paper/643/ Ziprasidone Spectrophotometric ZPD