Preparation, Characterization, Dissolution and Bioavailability of Hg(II) with Sulfathiazole

eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2007 3 2 153 158 juc 655 article Preparation, Characterization, Dissolution and Bioavailability of Hg(II) with Sulfathiazole Pawan Kumar 1 Veena Arora (drvarora@gmail.com 1 Ram Naresh Sharma 1 Department of Chemistry, K.N. Government Postgraduate College, Gyanpur, SRN-Bhadohi - 221 304 (INDIA) The interaction of sulfa drug sulfathiazole (STZ) with mercury(II) has been analyzed and solid complex was isolated and characterized by elemental and thermal analysis, FT-IR, 1H NMR spectral and electrical conductivity measurements. These studies suggest that the coordination of Hg(IIl with the Nthiazole atom forms stable STZ-Hg(II) complex. The structure of formula Hg(CTZ)2 complex has been proposed. The complex was screened for its activity against Escherichia coli and other microorganisms, showing an appreciable antimicrobial activity with the ligand. We observe greater dissolution rate of complex than pure STZ.     https://journalofchemistry.org/paper/655/ sulfathiazole FT-IR spectroscopy dissolution antimicrobial activity