eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2007 3 2 173 178 juc 659 article SYNTHESIS AND ANTICONVuLSANT ACTIVTTY OF 6-(3'- NITROPHENYL)-4-SUBSTITUTED BENZYLIDiNE-2,3,5-TRIHYDRO PYRIDAZIN-3-ONE Anees A Siddiqui 1 Mojahidul Islam 1 Mohd. Asif 2 Chavi Asthana 2 Jamia Hamdard, Hamdard Nagar, New Delh -62 (INDIA) Institute of Pharmacy, Bundelkhand University, Jhansi, UP. (INDIA) <p style="text-align: justify;">6-(3&#39;-nitrophenyl)-4-substituted benzylidine-2,3,5-trihydro pyridazin-3-one derivatives are synthesized from 6-(3&#39;-nitrophenyl)-2,3,4,5-tetrahydro pyridazin-3-one by reaction with substiuted aldehydes. Friedal craft acylation of benzene in presence of anhydrous aluminium chloride yield &szlig;-benzoyl propionic acid. After nitration with H<sub>2</sub>SO<sub>4</sub> and HNO<sub>3</sub> of the propionic acid yield &szlig; -m-nitrobenzoyl propionic acid, which is cyclised with hydrazine hydrate to form 6-(3&#39;-nitrophenyt)-2,3,4,5-tetrahydro pyridazin-3-one. Ali the</p> <p style="text-align: justify;">final synthesized compounds are evaluated for anticonvulsant activity by MES (maximal electro shock) method.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</p> <p style="text-align: justify;">&nbsp;</p> https://journalofchemistry.org/paper/659/ Pyridazinone Anticonvulsant activity..