eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2007 3 2 179 184 juc 660 article R. L. SAWANT 1 M. S. BHATIA 2 JYOTI B. WADEKAR 2 3 P.D.V.V.P.Fs College of Pharmacy, Vilad Ghat, Post - MIDC , Ahmednagar-414111 (MS) INDIA Bharti Vidyapeeth College of Pharmacy, Kolhapur- 416 013 (MS) (INDIA) <p style="text-align: justify;">(11Z)-11-(4-Substitutedphenyl) dibenzo[b,f][1,4]diazocin-6(5H)-ones<strong> (2a-e)</strong> have been synthesized. The substituents at fourth position of the phenyl ring for initial and final set of compounds have been selected according to Topliss modified approach. The synthesized compounds were structurally characterized by TLC, elemental analysis, IR and NMR spectra studies. The anticonvulsant potential of synthesized compounds was evaluated by using Rotarod, Actophotometer and Electroconvulsometer. The anticonvulsant activity evaluation of initial set of compounds <strong>(2a-d)</strong> revealed that electron releasing substituents with high lipophilicity if placed at fourth position in phenyl ring should increase the anticonvulsant activity. Based on this observation, 4-dimethylamino substituted compound <strong>(2e)</strong> was synthesized and found to have increased activity.</p> <p style="text-align: justify;">&nbsp;</p> https://journalofchemistry.org/paper/660/ Dibenzo Topliss approach Anticonvulsant activity