eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 April 2009 5 1 95 100 juc 687 article A.A. Siddiqui 1 Shadab A. Siddiqui 1 K.K Jha 2 Shalini Sawhney 3 Department of Pharmaceutical, Hamdard University, New Delhi - 110062 (INDIA) Department of Pharmaceutical, Chemistry, MIET, Meerut U.P. (INDIA) Department of Pharmaceutical, Chemistry, ITS College, Muradabad, Ghaziabad (INDIA) <p style="text-align: justify;">Two series of compounds (i) 2- substituted phenyl-10H-Pyridazin (6, 1-b) quinazoline-10-one (<strong>4</strong>a-g) and (ii) 6-substituted Phenyl tetrazolo (1, 5-b) pyridazine (<strong>5</strong>a-g) were synthesized. These compounds were evaluated for their hypotensive and anticonvulsant activities. These drugs showed the hypotensive activity ranging from 17.8 to 27.4% while standard drug minoxidil showed 27% reduction in blood pressure. All these compounds showed significant anticonvulsant activity when compared with phenytoin.</p> https://journalofchemistry.org/paper/687/ compounds anticonvulsant Pyridazin