eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 August 2009 5 2 153 158 juc 699 article K.P. Namdeo 1 Sweemit Kumar Jiwane 2 B. Sharma 2 S.K. Prajapati 2 SLT Institute of Pharmaceutical Science Guru Ghasidas Universtiy, Bilaspur (CG) INDIA Institute of Pharmacy, Bundelkhand University, Jhansi (UP) INDIA <p>A number of 2, 4-thiazolidinedione derivative having dialkyl amine/diphenylamine appendage at N-3 position were synthesized and their anti-inflammatory and antidiabetic activities were evaluated. Some new derivatives were synthesized by reaction of 2, 4-thiazolidinedione and different aldehydes, which react with different dialkylamine. In order to confirm anti-inflammatory and anti-hyperglycemic activity, the reduction in the paw volume of carrageenan induced oedema in the albino rat compared to Diaclofenac sodium and the blood glucose levels were determined according to GOD-POD method in dexamethasone diabetic rats respectively. All the compounds were found active for their anti-inflammatory activity and glucose lowering capability.</p> <p>&nbsp;</p> <p><em>Key words :</em> 2, 4-Thiazolidinedione, anti-inflammatory activity, antidiabetic activity, hypoglycemic agents, antihyperglycemics and Dialkyl Amine containing 2,4-Thiazolidinedione.</p> https://journalofchemistry.org/paper/699/ anti-inflammatory activity antidiabetic activity hypoglycemic agents antihyperglycemics and Dialkyl Amine containing 2 4-Thiazolidinedione