Synthesis of fluoro pyrazoles of Pharmacological interest

eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 August 2009 5 2 169 176 juc 702 article Synthesis of fluoro pyrazoles of Pharmacological interest Barot Hitesh K. 1 D.S. Puranik 1 Mallika G 1 Robin Jose 1 Shantharam U 1 L.V.G. Nargund 1 P.G. Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 (INDIA) We have synthesized (2E)-N-(3-chloro-4-fluorophenyl)-2-cyano-3-(methylthio)-3-[(substituted phenyl)amino]acrylamide by using different aryl amines and that reacted with hydrazine hydrate or 2,4-DNP to obtain series of 5-amino-N-(substituted-phenyl)-1-(substituted)-3-[(3-chloro-4-fluorophenyl) amino]-1H-pyrazole-4-carboxamide. The structures of new compounds were established on the basis of spectral and elemental analysis. The title compounds were screened for anti-bacterial (agar diffusion method) and anti-oxidant activity (ferric ion reduction method) and inhibition of denaturation of protein. Most of the compounds have shown promising activity.     https://journalofchemistry.org/paper/702/ Fluoro Pyrazole inhibition of denaturation of protein anti-bacterial activity anti-oxidant activity