eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 August 2009 5 2 265 270 juc 717 article MD. Shamim Ahmed 1 R.D. Hiremath 1 Farida Begum 1 Anurag Singh Mishra 1 J. Raghavendra 1 Shantharam U 1 L.V.G. Nargund (lvgnargund@rediffmail.com) 1 Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 Karnataka (INDIA) <p style="text-align: justify;">In view of various biological activities of cinnoline derivatives like antibacterial, antioxidant, antineoplastic it was our interest to prepare fluoro-pyrimido-cinnolines and then substitute it with various anilines, morpholine, piperazine and to evaluate them for antimicrobial activity. Fluoro-pyrimido-cinnoline was synthesized by reaction between 4-fluoro-3-chloro-aniline with sodium nitrite in presence of conc. HCI to form diazonium salt solution. This on treatment with ethyl cyano-acetamide gives aryl-hydrazino(cyano)acetamide which reacts with chlorobenzene in the presence of AlCl₃ to form 4-amino-3-cinnolino carboxamides which was further refluxed with formamide to give fluoro-pyrimido-cinnolines. Various fluoro-pyrimido-cinnoline derivatives were prepared by refluxing with morpholine, piperazine and substituted anilines in the presence of acetonitrile for 3-4 hours.</p> https://journalofchemistry.org/paper/717/ Synthesis of fluoro cinnolino pyrimidine compounds antibacterial activity