Synthesis and anticonvulsant activity of 2-(substituted phenylimino)-3-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazolidin-4-one

eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2008 4 2 175 178 juc 726 article Synthesis and anticonvulsant activity of 2-(substituted phenylimino)-3-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazolidin-4-one Siddiqui N. 1 Arshad M.F. 1 Khan S.A. 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jami Hamdard (Hamdard University), Hamdard Nagar, New Delhi - 110062 (INDIA) <p style="text-align: justify;"><br /> Some 2-(substituted phenylimino)-3-(5-substituted phenyl-1, 3, 4-thiadiazol-2-yl)-1, 3-thiazolidin-4-ones were synthesized in good yields by appropriate synthetic route and characterized on the basis of spectral data and elemental analysis. The compounds were evaluated for anticonvulsant activity. The compounds 4a, 4c, 4e, 4f, 4i and 4j were potent in MES test and were less neurotoxic comparable to standard drug phenytoin.<br />  </p> https://journalofchemistry.org/paper/726/ Thiadiazole Thiazolidinones Anticonvulsant Neurotoxicity