Synthesis of 2-imino-4-oxo-thiazolidino based quinoxalinediones as antitubercular agents

eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2008 4 2 189 194 juc 729 article Synthesis of 2-imino-4-oxo-thiazolidino based quinoxalinediones as antitubercular agents P.Y. PAWAR 1 S.B. BHISE 2 P.D.V.V.P. Fs, College of Pharmacy, Post MIDC, Vilad Ghat, Ahmednagar - 414 111, (MS) INDIA Government College of Pharmacy, Karad - 415 124 (MS) INDIA 6,7-bis[3-(4-substitutedphenyl)-4-oxo-thiazolidin-2-ylideneamino] quinoxa line-2,3(1H,4H)-diones (3a-e) have been synthesized by cyclisation of 6,7-bis[3'-aryl thiocarbamido]-quinoxaline-2,3(1H, 4H)-diones (2a-e) in presence of mono-chloroacetic acid, sodium acetate and glacial acetic acid. 6,7-Bis[3'-aryl thiocarbamido]-quinoxaline-2,3(1H,4H) -diones were obtained by reaction of 6,7-diaminoquinoxaline-2,3(1H,4H)-dione with substituted aromatic isothiocyanate. The constitution of the synthesized compounds is supported by IR, 1H NMR, Mass and elemental analysis. The compounds were subjected to preliminary in-vitro evaluation for antitubercular activity against Mycobacterium tuberculosis H37RV strain.   https://journalofchemistry.org/paper/729/ Quinoxaline-2 antitubercular activity