Synthesis and Reactions of 3-Cyano-4,6-Dimethyl- (2-Substituted) Pyridines Likely to Possess Biological Activity

eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2008 4 2 221 230 juc 733 article Synthesis and Reactions of 3-Cyano-4,6-Dimethyl- (2-Substituted) Pyridines Likely to Possess Biological Activity F.A. Yassin 1 Chemistry Department, Faculty of Science, Zagazig University, Zagazig (EGYPT) <p style="text-align: justify;">Reaction of 2-chloro-4,6-dimethylpyridine-3-carbonitrile (2) with each of hydrazine hydrate, hydroxylamine and anthranilic acid afforded the corresponding pyrazolo, isoxazolo and pyridoquinazoline derivatives (3), (4) and (5) respectively. Alkylation of 2-mercapto-4,6-dimethylpyridine-3-carbonitrile (7) with ethyl chloroacetate and/or phenacyl bromide followed by cyclisation in NaOH gave thienopyridine derivatives (9) and (12). Diazotization of ethyl 3-amino-4,6-dimethylthio[2,3-b]pyridince-2-carboxylate (9) followed by reaction with thiourea, guanidine carbonate and/or hydroxylamine hydrochloride gave the corresponding thienopyridine derivatives (15), (16) and (17) respectively. The biological activity of some new compounds has been discussed.<br />  </p> https://journalofchemistry.org/paper/733/ pyridine-3-carbonitrile pyrazolopyridine isoxazolo-pyridine pyridoquinazolino antibacterial activity.