eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 June 2008 4 1 65 70 juc 762 article ANEES A SIDDIQUI 1 BHAWNA SHARMA 2 K.P. NAMDEV 3 DEEPA CHAUHAN 3 Faculty of Pharmacy, Jamia Hamdard, Hamdard Nagar, New Delhi - 110062 (INDIA) Deptt. of Pharmacy, Bundelkhand University, Jhansi (INDIA) Deptt. of Pharmacy, ITS, Muradnagar, Ghaziabad, (INDIA) <p>[6-oxo-3-(substituted phenyl)-5,6-dihydro-4H-pyridazine-1-yl] acetic acid hydrazide derivatives were synthesized from [6-oxo-3-(p-substituted phenyl)-5,6-dihydro-4H-pyridazine-1-yl] acetic acid ethyl ester. Friedal craft acylation of substituted aromatic hydrocarbon in the presence of anhydrous aluminium chloride yield b-( p-substituted benzoyl) propionic acid. After the reaction with hydrazine hydrate the b-(p-substituted phenyl) propionic acid yield 6-(p-substituted phenyl)-2,3,4,5-tetrahydro-pyridazine-3-one that on reaction with ethylbromoacetate yield ethyl ester of the appropriate pyridazinone. The final compounds were synthesized by reaction of [6-oxo-3-(p-substituted phenyl)-5,6-dihydro-4H-pyridazine-1-yl] acetic acid ethyl ester with hydrazine hydrate. The synthesized compounds were tested for anticonvulsant activity by MES (maximal electro shock) method.<br /> &nbsp;</p> https://journalofchemistry.org/paper/762/ Pyridazinone Acid hydrazide Anticonvulsant activity.