Synthesis of 4-thiazolidinone derivatives for potential antifungal activity

eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2007 3 1 1 6 juc 779 article Synthesis of 4-thiazolidinone derivatives for potential antifungal activity Anees A. Siddiqui, 1 Aftab 1 M. Islam 1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Hamdard University, New Delhi - 110062 (INDIA) <p style="text-align: justify;">The final 4-thiazolidinone derivatives (4a-r) were synthesized from methyl acrylate/methmethyl acrylate and studied in vitro for antifungal activity against <em>A. niger, C. albicans, A. flavus, T. rubrum, A. fumigatus</em> and <em>P. citrinium</em> at the concentration of 40, 80 and 160 µg/ml. These compounds showed good antifungal activity. Compound 4a with p-chloro substitution at both the phenyl ring showed activity even better than the used standard drug, Voriconazole.</p> <table border="0" cellpadding="5" cellspacing="0" style="height:2274px; width:100%"> <tbody> <tr> <td> <p> </p> </td> </tr> <tr> <td> <hr /></td> </tr> </tbody> </table> https://journalofchemistry.org/paper/779/ antifungal activity thiazolidinone