eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 June 2006 2 2 104 106 juc 813 article SARITA SHRIVASTAVA 1 A. CHITRA REKHA TIWARI 1 Department of Chemistry, Govt. M.V.M., Bhopal <p style="text-align: justify;">Peptic ulcer is mainly caused by stress and dietary factors. Gastric acid is responsible for peptic ulcer. Proton pump inhibitors (PPI) play important role to suppress the stomach acids. Omeprazole is one of the important PPI drug. The interaction of Cd (11), Co (11), Cu (11), Mn (11) and Zn (11) ions with Omeprazole, in presence of a amino-acid, b-Alanine, has been investigated potentiometrically at 26&deg;C and 36&deg;C&nbsp; and at 0.1M (NaNO3) ionic strength. The stability constants of the Binary (1:1) and ternary (l:l:l) complexes indicate the stability order as : Co (11)&lt; Cu (11) &lt; Mn (11) &lt; Zn (11) &lt; Cd (11). D log K values obtained are positive and suggest greater stabilisation of ternary complexes. The calculated values of thermodynamic parameters (D G, D H and D S) indicate that the interactions are enthalpy characterised.<br /> &nbsp;</p> https://journalofchemistry.org/paper/813/ Proton pump inhibitors Omprazole stability of Omeprazole complexes