eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 June 2006 2 2 147 156 juc 820 article E. Jayachandran 1 G. M. Sreenivasa, L.V.G. Nargund 2 I. Shanmukha 2 P.M. Gaikwad 2 P.G. Department of Pharmaceutical Chemistry, S.C.S. College of Pharmacy, Harapanahalli - 583131 (INDIA) Nargund Colleg pf Pharmacy, Datatreya Nagar, BSK-III, Stage, Bangalore - 560 071 (INDIA) <p style="text-align: justify;">4-Fluoro-3-chloro aniline treated with potassium thiocyanate in the presence of acetic acid and bromine were converted into 2-amino-6-fluoro-7-chloro (1,3)-benzothiazole which was further treated with hydrazine hydrate in the presence of ethylene glycol results 2-hydrazino-6-fluoro-7-chloro(1,3)-benzothiazole,&nbsp; which was further treated with various aldehydes in the presence of ethanol and HCl results (substituted benzyl hydrazino)-6-fluoro-7-chloro-(1,3)-benzothiazole.&nbsp; It was treated with azomethane in dioxan to a well stirred mixture of chloroacetyl chloride and triethyl amine results to obtain compounds. The above said compound was refluxed with equimolar quantities of various substituted primary and secondary amines for two hours in the presence of dimethyl formamide to obtain different respective azetidinones derivatives.&nbsp; Some of the compounds have promising anti-inflammatory and anthelmintic activity.&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br /> &nbsp;</p> https://journalofchemistry.org/paper/820/ Fluorine Benzothiazoles azetidinone