eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 December 2009 5 3 315 322 juc 864 article EMAN A. SOBHY 1 HAMAD. M.I. HASAN 2 HASAN M. ALI 2 Omar Al- Mokthar University, Libya Ain -Shames University (EGYPT) <p style="text-align: justify;">The present study was performed to investigate the pharmacodynamic and nephrotoxic effect of royal jelly. Royal jelly stimulate the contractility of guinea pigs ileum, rat&#39;s colon and rabbits duodenum, this stimulant effect might be due to increasing influx of calcium ion. Royal jelly had direct myogenic action on uterine muscle at different stages of sex cycle, and also had positive inotropic effect on guinea pig&#39;s auricle and rabbit heart. 15 mg /kg. body wt of royal jelly was prodcued hypotensive effect in anasthetized dog due to direct relaxant effect of royal jelly on vascular muscle, on the other hand royal jelly had significant antipyretic and analgesic effect in rats. About nephrotoxic effect, royal jelly produced highly significant increase in serum creatinin and urea with significant decrease in creatinine and urea clearance. Royal jelly had significant hypoglycemic effect which migh be attributed to, the royal jelly had insulin like effect which reduced blood glucose level.</p> https://journalofchemistry.org/paper/864/ Pharmacological Royal Jelly