eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 March 2018 14 2 50 56 http://dx.doi.org/10.22147/juc/140201 880 article ROHIT. R. WAKODKAR 1 GAJANAN SANAP 1 MAZAHAR FAROOQUI 2 DEEPAK D. KAYANDE 1 Department of chemistry, Saraswati Bhuwan College of Science, Aurangabad, 431004 (M.S.) (India) Department of Chemistry, Dr. Rafiq Zakaria College for Women, Aurangabad (India) <p style="text-align: justify;">A convenient four-component synthesis of 6-amino-4-alkyl/aryl-3-methyl-2,4-dihydropyrano[2,3- c]pyrazole-5-carbonitriles.They are widely used for industrial purposes and also exhibit a broad range of antimicrobial activity. They are synthesized by using ethylacetoacetate, hydrazine hydrate, malononitrile, and various aldehydes using Tetra n-butyl ammonium bromide (TBAB) as a catalyst and water as solvent under mild reaction conditions. This method has several advantages such as high yield, mild reaction condition, operational simplicity, easy work-up procedure with environment friendly nature.</p> https://journalofchemistry.org/paper/880/ Pyranopyrazoles Tetra n-butyl ammonium bromide (TBAB) Aqueous medium Multicomponent reactions