eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 May 2019 15 3 39 42 http://dx.doi.org/10.22147/juc/150303 899 article RASHIDA QURESHI 1 MANISH SINGH 1 Department of Chemistry, Saifia College of Science & Education Bhopal (India) <p style="text-align:justify">Gliclazide, N-(4-Methyl Benzene Sulphonyl)-N-(3-azo bicycle (3,3,0-Oct-3-yl) urea trade name Diamicron, an oral hypoglycemic agent was used to synthesize its complex with Ag(I). The hypoglycemic activity of gliclazide was observed on experimental animals (dogs) and then compared with Ag Complex, using Folin-Wu method. Results reveals that the gliclazide Ag-Complex is more effective than that of parent drug.This blood sugar lowering effect of sulfonylureas seems to be related to the stimulation of insulin secretion. On the other hand many studies have strongly indicated the presence of long term or extra pancreatic action of sulfonylureas. The interesting observation on metal complex of oral sulfonylurea used as anti-diabetic agent for lowering blood sugar concentration may likely substantiates the use of these complex after extensive clinical studies.</p> https://journalofchemistry.org/paper/899/ Silver complex ,Hypoglycemic Activity Diabetes Melitus Antidiabetics