eng Ansari Education and Research Society Journal of Ultra Chemistry 0973-3450 2319-8036 September 2020 16 5 63 71 http://dx.doi.org/10.22147/juc/160503 912 article SUSHMA KUMARI 1 Dept. of Chemistry, V. K. S. University, Ara (India) <p>Valerates and Substituted Valerates have been found to be useful for humanbeings as its hydrolysis product i.e. valence acid is used in the society in the form of perfumes flavours platister, vinyl stabilizer and pharmaceuyicals.<br /> With a views to study the solvent effect of 1:4 dioxan on the biochemical behivour of the hydrolysis product of a substituted valerate, the kinetic of Alkali catalysed of mothyl iso-valerate was studies in aquodioxan media.<br /> Increase observed in free energy activation with simultaneous increase in the value of both the activation H* and S*, it is concluded that in the presence of dioxan with reaction media, the reaction becomes enthaipy dominating and entropy controlled.<br /> From the evaluated values of the reaction which comes to be 329.0, it is inferred that Barclay-Butler rule is obeyed by the reaction and there is strong solvent- solute interaction in presence of dioxan the reaction media.</p> https://journalofchemistry.org/paper/912/ Solvation and desolvation Barclay- Butler rule Solvent u2013Solute Interaction