Journal of Chemistry

Papers

Voulume: 18
Issue: 2
Article No. 1
In Silico ADME/ Tox profile of tetrasubstitutedazadipyrrins
Rahul Bhondwe
Department of Chemistry, TuljaramChaturchand College, Baramati, Maharashtra (India)
Nishant Nandkhile
Department of Chemistry, TuljaramChaturchand College, Baramati, Maharashtra (India)
Sachin Vanpure
Department of Chemistry, TuljaramChaturchand College, Baramati, Maharashtra (India)
Abstract :

We have explored the ADME (Absorption, Distribution, Metabolism and Excretion) profile of eight different derivatives of tetrasubstitutedaza-dipyrrins. Compound 1-9 are screened with the help of onlinewebtoolSwissADME. Studies were performed for pharmacokinetic, lipophilicity, water solubility, bioavailability and drug likeness properties. Compound 9 found to a optimum among all the compounds under investigation.

Keyword : Aza- Dipyrrins, Pyrrole,, ADME, SwissADME
Paper Download Count : 372
View Count : 476
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Article No. 2
A systematic review on diverse synthetic route and pharmacological activities of benzimidazole as optimized lead
SHANKAR THAPA
Department Of Pharmaceutical Chemistry, Nargund College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru-560085 (India)
SACHINDRA L. NARGUND
Department Of Pharmaceutical Chemistry, Nargund College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru-560085 (India)
MAHALAKSHMI SURESHA BIRADAR
Department Of Pharmaceutical Chemistry, Nargund College of Pharmacy, Rajiv Gandhi University of Health Sciences, Bengaluru-560085 (India)
Abstract :

The aim of this review is to provide the systematic information of synthetic scheme and biological activity of synthesized benzimidazole derivatives. Benzimidazole is widely used lead molecule for the synthesis of various types of pharmacologically active moiety. It is heterocyclic aromatic fused colorless solid having molecular mass of 118.053 g/mol. It is basic in nature and can be served as ligand in coordination chemistry. It is bioactive compound showed various pharmacological activity till now viz. anthelmintics (albendazole, mebendazole), proton pump inhibitors (omeprazole, pantoprazole), antibiotics, antiprotozoal, antifungal, anticancer, anti-viral, anti-oxidant, anti-inflammatory etc. Various synthetic route by various methods is also already reported. Some of them are traditional convenient method, microwave reactor method, solvent free synthesis method, green synthesis method. Due to its wide variety of biological action and the similarity with biomolecule, it is frequently taken as lead for new drug discovery

Keyword : benzimidazole derivatives, , bioactive, anti-cancer, anti-viral, antibiotic.
Paper Download Count : 398
View Count : 866
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