We have explored the ADME (Absorption, Distribution, Metabolism and Excretion) profile of eight different derivatives of tetrasubstitutedaza-dipyrrins. Compound 1-9 are screened with the help of onlinewebtoolSwissADME. Studies were performed for pharmacokinetic, lipophilicity, water solubility, bioavailability and drug likeness properties. Compound 9 found to a optimum among all the compounds under investigation.

The aim of this review is to provide the systematic information of synthetic scheme and biological activity of synthesized benzimidazole derivatives. Benzimidazole is widely used lead molecule for the synthesis of various types of pharmacologically active moiety. It is heterocyclic aromatic fused colorless solid having molecular mass of 118.053 g/mol. It is basic in nature and can be served as ligand in coordination chemistry. It is bioactive compound showed various pharmacological activity till now viz. anthelmintics (albendazole, mebendazole), proton pump inhibitors (omeprazole, pantoprazole), antibiotics, antiprotozoal, antifungal, anticancer, anti-viral, anti-oxidant, anti-inflammatory etc. Various synthetic route by various methods is also already reported. Some of them are traditional convenient method, microwave reactor method, solvent free synthesis method, green synthesis method. Due to its wide variety of biological action and the similarity with biomolecule, it is frequently taken as lead for new drug discovery