Characterization and screening of heterocyclic compounds for hypotensive activity
Author & Affiliation:
A.A. Siddiqui
Department of Pharmaceutical, Hamdard University, New Delhi - 110062 (INDIA)
Shadab A. Siddiqui
Department of Pharmaceutical, Hamdard University, New Delhi - 110062 (INDIA)
K.K Jha
Department of Pharmaceutical, Chemistry, MIET, Meerut U.P. (INDIA)
Shalini Sawhney
Department of Pharmaceutical, Chemistry, ITS College, Muradabad, Ghaziabad (INDIA)
Keyword:
compounds, anticonvulsant, Pyridazin
Issue Date:
April 2009
Abstract:
Two series of compounds (i) 2- substituted phenyl-10H-Pyridazin (6, 1-b) quinazoline-10-one (4a-g) and (ii) 6-substituted Phenyl tetrazolo (1, 5-b) pyridazine (5a-g) were synthesized. These compounds were evaluated for their hypotensive and anticonvulsant activities. These drugs showed the hypotensive activity ranging from 17.8 to 27.4% while standard drug minoxidil showed 27% reduction in blood pressure. All these compounds showed significant anticonvulsant activity when compared with phenytoin.
Pages:
95-100
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
PDF:
DOI:
juc
Copy the following to cite this article:
A. Siddiqui; S. A. Siddiqui; K. Jha; S. Sawhney, "Characterization and screening of heterocyclic compounds for hypotensive activity", Journal of Ultra Chemistry, Volume 5, Issue 1, Page Number 95-100, 2018Copy the following to cite this URL:
A. Siddiqui; S. A. Siddiqui; K. Jha; S. Sawhney, "Characterization and screening of heterocyclic compounds for hypotensive activity", Journal of Ultra Chemistry, Volume 5, Issue 1, Page Number 95-100, 2018Available from: http://journalofchemistry.org/paper/687/
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