The effect of thermal stress and alcohol stress given simultaneously to male albino mice was studied using locomotory behaviour as the assessment parameter in an open field arena. The mice were exposed to 0, 10, 20, 30 and 40 ºC ± 2ºC for 24 h before subjecting them to behavioural test. The animals were injected with 99% ethyl alcohol at the doses of 1 and 3 g/kg body weight (i.p.). The behavioural activities recorded at 20±2ºC were considered as the control activity at normal temperature. All locomotory activity observations were made in thermostatically controlled chamber at all specified temperatures and alcohol exposures. Locomotor activities including the numbers of square crossed, rears, wall rears and washes, decreased at lower temperatures and increased at higher temperatures as compared to the controls. Alcohol intoxication inflicted an inhibitory effect on all acts and postures in a dose dependent manner at all thermal stress. Locomotory and immobility durations of the animals during the test period were directly and inversely related to the stresses. These observations are discussed in the light of the thermal regulatory mechanism in the body and the possibility of studying these effects in perspective of the effects of thermal and alcohol stresses causing injuries in humans.