Synthesis and Antibacterial Activity of Some Novel Thiazino / Oxazino Pyrazole Derivatives

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Synthesis and Antibacterial Activity of Some Novel Thiazino / Oxazino Pyrazole Derivatives

Author & Affiliation:

Priyanka Kedia

Synthetical Organic Research Lab., Department of Chemistry, T.D.P.G. College, Jaunpur (U.P.) 222 002 (INDIA)

Vandana Singh

Synthetical Organic Research Lab., Department of Chemistry, T.D.P.G. College, Jaunpur (U.P.) 222 002 (INDIA)

Pooja Singh

Synthetical Organic Research Lab., Department of Chemistry, T.D.P.G. College, Jaunpur (U.P.) 222 002 (INDIA)

Mamta Singh

Synthetical Organic Research Lab., Department of Chemistry, T.D.P.G. College, Jaunpur (U.P.) 222 002 (INDIA)

Vidita Upadhyay

Synthetical Organic Research Lab., Department of Chemistry, T.D.P.G. College, Jaunpur (U.P.) 222 002 (INDIA)

Daroga Singh

Synthetical Organic Research Lab., Department of Chemistry, T.D.P.G. College, Jaunpur (U.P.) 222 002 (INDIA)

Keyword:

Pyrazoles, thiazino / oxazino-pyrazoles, Antibacterial activity of pyrazoles.

Issue Date:

August 2009

Abstract:

The condensation of 2,4-dihydro-2,5-disubstituted-3H-pyrazol- 3-ones (1) with substituted benzaldehyde (2) in presence of glacil acetic acid gives 4-arylmethylene-2,4-dihydro-2,5-disubstituted-3H- pyrazol-3-ones (3). Similarly, the 4-arylmethylene-2,4-dihydro-2,5- disubstituted-3H-pyrazol-3-ones (3) reacts with thioureal/ phenyl thiourea / urea/ phenyl urea in presence of alkaline solution of ethanol at reflux temperature to give l,3-disubstituted-4-substituted phenyl-6-imino / phenylimino-4,7 -dihydro-1,3-thiazino / oxazino [5,4-d] pyrazoles. The antibacterial activities of the compounds (4) were tested against S. aureus and B. cereus bacteria.

Pages:

271-278

ISSN:

2319-8036 (Online) - 0973-3450 (Print)

Source:

Vol.5 - No.2

PDF:

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DOI:

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Copy the following to cite this article:

P. Kedia; V. Singh; P. Singh; M. Singh; V. Upadhyay; D. Singh, "Synthesis and Antibacterial Activity of Some Novel Thiazino / Oxazino Pyrazole Derivatives", Journal of Ultra Chemistry, Volume 5, Issue 2, Page Number 271-278, 2018

Copy the following to cite this URL:

Available from: http://journalofchemistry.org/paper/718/

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