Reaction of 2-chloro-4,6-dimethylpyridine-3-carbonitrile (2) with each of hydrazine hydrate, hydroxylamine and anthranilic acid afforded the corresponding pyrazolo, isoxazolo and pyridoquinazoline derivatives (3), (4) and (5) respectively. Alkylation of 2-mercapto-4,6-dimethylpyridine-3-carbonitrile (7) with ethyl chloroacetate and/or phenacyl bromide followed by cyclisation in NaOH gave thienopyridine derivatives (9) and (12). Diazotization of ethyl 3-amino-4,6-dimethylthio[2,3-b]pyridince-2-carboxylate (9) followed by reaction with thiourea, guanidine carbonate and/or hydroxylamine hydrochloride gave the corresponding thienopyridine derivatives (15), (16) and (17) respectively. The biological activity of some new compounds has been discussed.
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F. Yassin, "Synthesis and Reactions of 3-Cyano-4,6-Dimethyl- (2-Substituted) Pyridines Likely to Possess Biological Activity ", Journal of Ultra Chemistry, Volume 4, Issue 2, Page Number 221-230, 2018Copy the following to cite this URL:
F. Yassin, "Synthesis and Reactions of 3-Cyano-4,6-Dimethyl- (2-Substituted) Pyridines Likely to Possess Biological Activity ", Journal of Ultra Chemistry, Volume 4, Issue 2, Page Number 221-230, 2018Available from: http://journalofchemistry.org/paper/733/