Reaction of Amoxicillin & Alanine with certain biologically active metal ions, in binary & ternary systems have been traced conductometrically & spectrophotometrically. Formation of M : Ala : Amox, 1 : 1 & 1 : 2 complexes and M : Ala : Amp. 1 : 1: 1 complex is indicated, structures of the isolated mixed complexes with the metal : Alanine : Amoxicillin in 1 : 1: 1 molar ratio have been ascertained on the basis of analytical data and physico-chemical properties. The results of the study appear to support the hypothesis that formation of metal bridged-drug-receptor complex is formed during antibiotic activity of the drug.