SYNTHESIS OF FLUORO-PYRAZOLES FOR ANTIBACTERIAL ACTIVITY
Author & Affiliation:
SHACHINDRA L. N.
Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 Karnataka (INDIA)
D.S. PURANIK
Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 Karnataka (INDIA)
L.V.G. NARGUND
Department of Pharmaceutical Chemistry, Nargund College of Pharmacy, Dattatreyanagar, BSK III Stage, Bangalore- 85 Karnataka (INDIA)
Keyword:
FLUORO, ANTIBACTERIAL ACTIVITY
Issue Date:
June 2008
Abstract:
4-fluoro-3-chloro-anilin(1) react with various aromatic aldehydes(2) under mild acid catalysed conditions to get 4-fluoro-3-chloro-arylednes (3). These aryledenes were further reacted with hydrazine hydrate to get 4-fluoro-3-hydrazino-arylidenes (4), which further reacted with acetylacetone to afford compounds. 3,5-dimethyl (-N-21-fluoro-51-(3,4,5-trimethoxyaryledene) pyrazole (6b) has shown marked activity against E. Coli and S. aureus. at 100mcg and 200mcg concentration.
Pages:
61-64
ISSN:
2319-8036 (Online) - 0973-3450 (Print)
Source:
PDF:
DOI:
juc
Copy the following to cite this article:
S. L. N.; D. Puranik; L. Nargund, "SYNTHESIS OF FLUORO-PYRAZOLES FOR ANTIBACTERIAL ACTIVITY", Journal of Ultra Chemistry, Volume 4, Issue 1, Page Number 61-64, 2018Copy the following to cite this URL:
S. L. N.; D. Puranik; L. Nargund, "SYNTHESIS OF FLUORO-PYRAZOLES FOR ANTIBACTERIAL ACTIVITY", Journal of Ultra Chemistry, Volume 4, Issue 1, Page Number 61-64, 2018Available from: http://journalofchemistry.org/paper/761/
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