Reaction of Amoxicillin & Alanine with certain biologically active metal ions, in binary & ternary systems have been traced conductometrically & spectrophotometrically. Formation of M : Ala : Amox, 1:1 & l:2 complexes and M : Ala : Amp. l:1:1 complex is indicated, structures of the isolated mixed complexes with the metal : Alanine : Amoxicillin in l:l:l molar ratio have been ascertained on the basis of analytical data and physico-chemical properties. The results of the study appear to support the hypothesis that formation of metal bridged drug­receptor complex is formed during antihiotic activity of the drug.