4-Fluoro-3-chloro aniline treated with potassium thiocyanate in the presence of acetic acid and bromine were converted into 2-amino-6-fluoro-7-chloro (1,3)-benzothiazole which was further treated with hydrazine hydrate in the presence of ethylene glycol results 2-hydrazino-6-fluoro-7-chloro(1,3)-benzothiazole, which was further treated with various aldehydes in the presence of ethanol and HCl results (substituted benzyl hydrazino)-6-fluoro-7-chloro-(1,3)-benzothiazole. It was treated with azomethane in dioxan to a well stirred mixture of chloroacetyl chloride and triethyl amine results to obtain compounds. The above said compound was refluxed with equimolar quantities of various substituted primary and secondary amines for two hours in the presence of dimethyl formamide to obtain different respective azetidinones derivatives. Some of the compounds have promising anti-inflammatory and anthelmintic activity.
Copy the following to cite this article:
E. Jayachandran; G. M. S. L. Nargund; I. Shanmukha; P. Gaikwad, "INHIBITION OF ALBUMIN DENATURATION (ANTI-INFLAMMATORY) AND ANTHELMENTIC ACITIVITY OF FLUORO SUBSTITUTED BENZOTHIAZOLES COMPRISING AZETIDINONES", Journal of Ultra Chemistry, Volume 2, Issue 2, Page Number 147-156, 2018Copy the following to cite this URL:
E. Jayachandran; G. M. S. L. Nargund; I. Shanmukha; P. Gaikwad, "INHIBITION OF ALBUMIN DENATURATION (ANTI-INFLAMMATORY) AND ANTHELMENTIC ACITIVITY OF FLUORO SUBSTITUTED BENZOTHIAZOLES COMPRISING AZETIDINONES", Journal of Ultra Chemistry, Volume 2, Issue 2, Page Number 147-156, 2018Available from: http://journalofchemistry.org/paper/820/