Ziprasidone is a typical antipsychotic agent. Two simple, sensitive and accurate spectrophotometric methods have been developed for the determination of Ziprasidone hydrochloride (ZPD) in pure state and in its pharmaceutical formulations. The developed Method A is based on the diazocoupling reaction of the Brotton-Marshall's reagent with drug and it shows maximum absorption at max 540 nm; Linearity in the range of 2-10 pg/mL. Method B is based on the reaction between drug and 1, 10-phenanthroline with ferric chloride and orthophosphoric acid to form a colored chromogen and it shows maximum absorption at A. ,_nax 520 nm and Linearity in the range of 4-20 pg/mL. The results obtained were statistically evaluated and were found to be accurate and reproducible.