1MES College of Pharmacy, Bangalore india
2KVR Siddartha College of Pharmacy, Vijayawada India
Government College of Parmacy, Bangalore India
Email:- bksoni19@gmail.com
A series of novel pyrazoles were synthesized starting from 4- fluoro-3-chloroaniline by condensation with aromatic aldehydes to give chalcones which were cyclized with hydrazine to obtain pyrazoles. The chlorine replaced various aromatic amines to obtain the final derivatives. The final compounds evaluated for in vitro bovine serum denaturation assay and in vivo antinflammatory activity by carrageenan induced rat paw oedema. The study indicated the importance of chlorine at the para position of the aromatic ring in enhancing antiinflammatory activity. Correlation with enzyme inhibition scores also explained.
Copy the following to cite this article:
BRIJENDRA KUMAR SONI*1, G. DEVALA RAO2 and SHANTHARAM UMESH NAYAK3, "Synthesis and Evaluation of Some Novel Pyrazoles for Antinflammatory Studies", Journal of Ultra Chemistry, Volume 10, Issue 3, Page Number 145-154, 2016Copy the following to cite this URL:
BRIJENDRA KUMAR SONI*1, G. DEVALA RAO2 and SHANTHARAM UMESH NAYAK3, "Synthesis and Evaluation of Some Novel Pyrazoles for Antinflammatory Studies", Journal of Ultra Chemistry, Volume 10, Issue 3, Page Number 145-154, 2016Available from: http://journalofchemistry.org/paper/313/